Repeated Reiki sessions may influence neurological pathways involved in treatment-resistant depression by affecting brainwave activity, stress-related hormone release, and limbic system regulation. Anecdotal reports and pilot studies suggest that regular Reiki practice induces alpha and theta wave dominance, which are brainwave states associated with deep relaxation, emotional processing, and creative insight. These changes can facilitate increased neuroplasticity and potentially support shifts in entrenched emotional patterns associated with chronic depressive states.
Some small-scale studies have observed reductions in cortisol levels and improvements in subjective mood assessments following a series of Reiki sessions. While these findings are promising, large-scale randomized controlled trials remain scarce. The hypothalamic-pituitary-adrenal (HPA) axis appears to be a potential mediator in this process, as Reiki recipients often show measurable decreases in salivary cortisol and increased parasympathetic nervous system activity, both of which are disrupted in depression.
More robust clinical trials using neuroimaging technologies such as fMRI or EEG are needed to explore changes in amygdala activation or default mode network behavior after Reiki interventions. If consistent neurological improvements can be observed, Reiki may serve as a valuable adjunctive therapy for individuals who do not respond to medication or traditional psychotherapy. Its non-invasive nature makes it a viable candidate for integrative psychiatric care models.